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US 12,697,392 B2Granted
Quinone protected forms and conjugates
AssigneeCambridge Enterprise Limited
InventorsGonçalo Bernardes, Lavinia Couturier, Julie Becher, Enrique Gil De Montes Rojas
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Abstract
The invention provides protected ortho-quinone compounds comprising a group represented by: where —Ar— is optionally substituted phenylene, —X is selected from —NH2, —OH and —SH, and the protected forms of each, —W— is optionally substituted methylene, such as methylene, and d is a double or single bond, and the salts and solvates thereof.
Claims24
A protected ortho-quinone compound comprising a group represented by:
- where —Ar— is a phenylene or a substituted phenylene,
- —X is selected from —NH2, —OH and —SH, and the protected forms of each,
- —W— is a methylene or a substituted methylene,
- d is a double or single bond, and
- the ketol form of the ortho-quinone is selected from the group consisting of β-Lapachone, Rhinacanthone, Dunnione, Biflorin, Tanshinone I, Tanshinone IIA, Tanshinone IIB, Dihydrotanshinone I, Cryptotanshinone, Mansonone A, Mansonone C-G, Miltirone, Salvicine, Caryopteron A, Lantalucratin A-C, pyrroloquinolone quinone and 3-hydroxy-β-lapachone, and the salts and solvates thereof.
2 more elements
Dependencies are inferred from the claim text.