Use of diketone compound in photodynamic therapy or diagnosis
AssigneeBeijing Wholesometech Co., Ltd.
InventorsNing Jiao, Jialiang Wei, Yameng Liu
Life of this patent
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Abstract
The disclosure belongs to the technical field of medicine, and relates to use of a diketone compound in photodynamic therapy or diagnosis. Particularly, the disclosure relates to use of a compound of formula (I), pharmaceutically acceptable salt or ester, prodrug, stereoisomer, hydrate, solvate or crystal form of the compound, metabolite of each of them, or any combination or mixture thereof in preparation of a drug or a reagent. The drug or the reagent is used for photodynamic therapy or photodynamic diagnosis of a disease or is used for skin beauty by means of photodynamic therapy.
Claims13
A photodynamic method of treating a disease in a subject suffering from the disease, the method comprising administering a compound of Formula (I):
- a pharmaceutically acceptable salt or ester, a stereoisomer, or a crystal form, or any combination or mixture thereof;
- and irradiating the subject with a light after the administering;
- wherein the disease is selected from breast cancer, cervical cancer, colon cancer, and skin cancer;
- and
- wherein R1 and R2 of Formula (I) are each independently a linear or branched alkyl with 1 to 6 carbon atoms, a halogenated linear or branched alkyl with 1 to 6 carbon atoms, a hydroxyl group, or the following groups optionally substituted with one or more same or different substituents comprising aryl with 6 to 14 carbon atoms, 5- to 6-membered heteroaryl, 5- to 6-membered heterocyclyl, and 3- to 6-membered cycloalkyl, wherein the substituents are each independently selected from a hydroxyl group, a carboxyl group, a sulfonic group, a halogen atom, an amino group, a mercapto group, a nitro group, —C(O)O-(linear or branched alkyl with 1 to 4 carbon atoms), —S(O)2O-(linear or branched alkyl with 1 to 4 carbon atoms), or —O-(linear or branched alkyl with 1 to 4 carbon atoms);
- and
- wherein the compound of Formula (I), a pharmaceutically acceptable salt or ester, a stereoisomer, or a crystal form, or any combination or mixture thereof is administered as the only active ingredient.
A photodynamic method of treating a disease in a subject suffering from the disease, the method comprising administering a compound of Formula (I):
- a pharmaceutically acceptable salt or ester, a stereoisomer, or a crystal form, or any combination or mixture thereof;
- and irradiating the subject with a light after the administering;
- wherein the disease is related to a microorganism infection, and the microorganism is selected from human papilloma virus, Propionibacterium acnes and Escherichia coli;
- and
- wherein R1 and R2 of Formula (I) are each independently a linear or branched alkyl with 1 to 6 carbon atoms, a halogenated linear or branched alkyl with 1 to 6 carbon atoms, a hydroxyl group, or the following groups optionally substituted with one or more same or different substituents comprising aryl with 6 to 14 carbon atoms, 5- to 6-membered heteroaryl, 5- to 6-membered heterocyclyl, and 3- to 6-membered cycloalkyl, wherein the substituents are each independently selected from a hydroxyl group, a carboxyl group, a sulfonic group, a halogen atom, an amino group, a mercapto group, a nitro group, —C(O)O-(linear or branched alkyl with 1 to 4 carbon atoms), —S(O)2O-(linear or branched alkyl with 1 to 4 carbon atoms), or —O-(linear or branched alkyl with 1 to 4 carbon atoms);
- and
- wherein the compound of Formula (I), a pharmaceutically acceptable salt or ester, a stereoisomer or a crystal form, or any combination or mixture thereof is administered as the only active ingredient.
Dependencies are inferred from the claim text.