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US 12,697,383 B2Granted
Modified envelope protein of human immunodeficiency virus and use thereof
AssigneesXiamen University, Xiamen Innovax Biotech Co., Ltd.
InventorsYing Gu, Tingting Deng, Hui Zhang, Fang Huang, Gege Chen, Yanling Lin, Shaowei Li, Ningshao Xia
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Abstract
Provided are a newly designed HIV-1 Env trimer protein, and an HIV-1 pseudovirus and virus expressing the Env trimer protein, and the use thereof for the prevention and/or treatment of HIV infection.
Claims29
A recombinant protein, which comprises gp120 and gp41 ectodomain (gp41ECTO) derived from human immunodeficiency virus (HIV), wherein the gp120 is located between β27 and α8 of the gp41ECTO;
- and the recombinant protein comprises:
- α6, α7, β27 of gp41ECTO;
- gp120;
- α8, α9 of gp41ECTO, from its N-terminal to C-terminal;
- and wherein:
- (i) the gp41ECTO comprises a substitution of 1-12 consecutive amino acids in a linkage region between β27 and α8 with gp120;
- and wherein the linkage region corresponds to amino acid positions 607-618 of a gp160 sequence of isolate HXB2;
- or
- ii) the gp120 is inserted between adjacent amino acids in a linkage region between β27 and α8 of gp41ECTO;
- and wherein the linkage region corresponds to amino acid positions 607-618 of a gp160 sequence of isolate HXB2.
7 more elements
Dependencies are inferred from the claim text.