Baculovirus expression vector
AssigneeIntervet Inc.
InventorErwin Van Den Born
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Abstract
The invention concerns a baculovirus expression vector for recombinantly expressing a Foot-and-mouth disease virus (FMDV) capsid precursor protein under control of a promoter, the expression vector comprising a nucleic acid sequence encoding the FMDV capsid precursor protein, wherein the ATG start codon of an open reading frame encoding the FMDV capsid precursor protein is preceded at position −4 to −1 by the nucleic acid sequence 5′-AAAT-3′. The invention further relates to a host cell comprising the baculovirus expression vector, a method of producing FMDV virus-like particles (VLPs), and a method of producing a vaccine.
Claims13
A baculovirus expression vector for recombinantly expressing a Foot and mouth disease virus (FMDV) capsid precursor protein, the expression vector comprising a nucleic acid sequence encoding the FMDV capsid precursor protein under the control of a promoter, wherein the ATG start codon of an open reading frame encoding the FMDV capsid precursor protein is preceded at position −4 to −1 by the nucleic acid sequence 5′-AAAT-3′ and wherein the FMDV is of the Asia1 or SAT2 serotype.
Dependencies are inferred from the claim text.