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AssigneeZhejiang Free Trade Zone Hongan Base Biotechnology Co., Ltd.
InventorsBo Zhang, Hanqing Ye, Yanan Zhang, Na Li, Qiuyan Zhang, Chenglin Deng, Shaopeng Yuan, Shunli Zhan, Lei Gao
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Provided are an attenuated virus of a flavivirus virus and the use thereof. The attenuated virus comprises a polyadenylic acid (poly(A)) sequence, wherein the polyadenylic acid (poly(A)) is used for replacing a part of the nucleotide sequence of a 3′ untranslated region (3′UTR) of the flavivirus virus, so that the 3′ untranslated region (3′UTR) of the attenuated virus obtained after the part of the nucleotide sequence of the flavivirus virus is replaced at least retains a 3′-end stem loop region (3′SL). The attenuated virus can be used for preparing safe and effective attenuated vaccine strains.
An attenuated flavivirus virus, comprising a polyadenylic acid (poly(A)) sequence, wherein the polyadenylic acid (poly(A)) sequence is used for replacing a part of nucleotide sequence of a 3′ untranslated region (3′UTR) of the flavivirus virus, so that the 3′ untranslated region (3′UTR) of the attenuated flavivirus virus obtained in response to the part of the nucleotide sequence of the flavivirus virus being replaced at least retains a 3′-end stem loop region (3′SL), the flavivirus virus is West Nile virus (WNV) or dengue virus (DENV).
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