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US 12,697,368 B2Granted
TSG6 polypeptide fragment for dry eye disease
AssigneeThe University of Manchester
InventorsAnthony Day, Caroline Milner, Joo Youn Oh
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Abstract
Described herein is a treatment of dry eye disease and particularly, although not exclusively, to the treatment of dry eye disease with a LINK_TSG6 polypeptide.
Claims9
A method for treating dry eye disease (DED) in a subject, comprising administering topically to the subject one or more eye drops, wherein the one or more eye drops comprise an effective amount of a polypeptide comprising a Link module from Tumour necrosis factor-stimulated gene 6 (LINK_TSG6),
- wherein the LINK_TSG6 consists of (i) the amino acid sequence of SEQ ID NO:
- 7 or SEQ ID NO:
- 9, or (ii) the amino acid sequence having at least 90% identity to the amino acid sequence of SEQ ID NO:
- 7 or 9 and up to 100 amino acids in length;
- and
- wherein the treating comprises healing of a corneal epithelial defect, and wherein healing of the corneal epithelial defect is determined by a decrease in ocular staining score as compared to (i) the subject prior to the administering or (ii) an untreated control.
3 more elements
Dependencies are inferred from the claim text.