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AssigneeOsaka University
InventorsTakahisa Furukawa, Taro Chaya
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The present invention provides a medicament for improving or preventing a symptom relating to a retina and/or light reception, the medicament comprising, as an active ingredient, a substance capable of maintaining or enhancing the phosphorylation state of Unc119; a method for screening for a substance capable of improving or preventing a symptom relating to a retina and/or light reception, the method comprising the step of selecting a substance capable of inhibiting calcineurin, or selecting a substance capable of activating casein kinase 2; and an agent for inhibiting retinal degeneration and an agent for protecting a retina, the agents each comprising, as an active ingredient, a substance capable of maintaining or enhancing the phosphorylation state of Unc119.
A method for treating a symptom by maintaining or enhancing the phosphorylation state of Unc119 in a retina, the method comprising administering to a mammal in need thereof an effective amount of a calcineurin inhibitor, wherein the symptom is at least one retinal disease selected from the group consisting of dry age-related macular degeneration, retinitis pigmentosa, and Stargardt disease, and wherein the calcineurin inhibitor treats the symptom by maintaining or enhancing the phosphorylation state of Unc119.
A method of inhibiting retinal degeneration by maintaining or enhancing the phosphorylation state of Unc119, the method comprising administering to a mammal in need thereof an effective amount of a calcineurin inhibitor, wherein inhibiting the retinal degeneration is slowing down retinal degeneration, wherein the retinal degeneration is caused by at least one disease associated with a dephosphorylation state of Unc119 selected from the group consisting of dry age-related macular degeneration, retinitis pigmentosa, and Stargardt disease, and wherein the calcineurin inhibitor inhibits the retinal degeneration by maintaining or enhancing the phosphorylation state of Unc119.
Dependencies are inferred from the claim text.