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AssigneeMayo Foundation for Medical Education and Research
InventorsRichard G. Vile, Laura Evgin, Amanda L. Huff, Christopher B. Driscoll, Timothy J. Kottke, Jason M. Tonne, Jill M. Thompson, Brady N. Zell
Estimating the term…
This document provides methods and materials for treating cancer. For example, methods and materials for using oncolytic viruses (e.g., replication-competent vesicular stomatitis viruses) to treat cancer are provided. Replication-competent oncolytic viruses (e.g., replication-competent oncolytic vesicular stomatitis viruses), nucleic acid molecules encoding a replication-competent oncolytic virus (e.g., replication-competent oncolytic vesicular stomatitis virus), methods for making replication-competent oncolytic viruses (e.g., replication-competent oncolytic vesicular stomatitis viruses), methods for using replication-competent oncolytic viruses (e.g., replication-competent oncolytic vesicular stomatitis viruses) to treat cancer, cancer neoantigens, nucleic acids encoding a cancer neoantigen, and methods for stimulating immune cells (e.g., cytotoxic T lymphocytes) to kill cancer cells also are provided.
A method for treating cancer in a mammal, wherein said method comprises administering, to said mammal, (a) a replication-competent oncolytic virus and (b) a polypeptide comprising the amino acid sequence set forth in SEQ ID NO:1 or nucleic acid encoding said polypeptide, and wherein said cancer comprises melanoma or hepatocellular carcinoma.
A replication-competent oncolytic virus comprising nucleic acid encoding the amino acid sequence set forth in SEQ ID NO:1 or comprising a nucleic acid sequence that is a template for said nucleic acid encoding the amino acid sequence set forth in SEQ ID NO:1.
A composition comprising (a) a substantially pure polypeptide comprising the amino acid sequence set forth in SEQ ID NO:1 and (b) an adjuvant.
A replication-competent vesicular stomatitis virus comprising an RNA molecule, wherein said RNA molecule comprises a nucleic acid sequence that is a template for a positive sense transcript encoding a VSV N polypeptide, a nucleic acid sequence that is a template for a positive sense transcript encoding a VSV P polypeptide, a nucleic acid sequence that is a template for a positive sense transcript encoding a VSV M polypeptide, a nucleic acid sequence that is a template for a positive sense transcript encoding a VSV G polypeptide, a nucleic acid sequence that is a template for a positive sense transcript encoding the amino acid sequence set forth in SEQ ID NO:1, and a nucleic acid sequence that is a template for a positive sense transcript encoding a VSV L polypeptide, wherein said positive sense transcript encoding said VSV N polypeptide, said positive sense transcript encoding said VSV P polypeptide, said positive sense transcript encoding said VSV M polypeptide, said positive sense transcript encoding said VSV G polypeptide, and said VSV L polypeptide are each set forth within the nucleotide sequence of SEQ ID NO:16.
A nucleic acid molecule comprising a nucleic acid strand comprising a nucleic acid sequence that is a template for a positive sense transcript encoding a VSV N polypeptide, a nucleic acid sequence that is a template for a positive sense transcript encoding a VSV P polypeptide, a nucleic acid sequence that is a template for a positive sense transcript encoding a VSV M polypeptide, a nucleic acid sequence that is a template for a positive sense transcript encoding a VSV G polypeptide, a nucleic acid sequence that is a template for a positive sense transcript encoding the amino acid sequence set forth in SEQ ID NO:1, and a nucleic acid sequence that is a template for a positive sense transcript encoding a VSV L polypeptide, wherein said positive sense transcript encoding said VSV N polypeptide, said positive sense transcript encoding said VSV P polypeptide, said positive sense transcript encoding said VSV M polypeptide, said positive sense transcript encoding said VSV G polypeptide, and said VSV L polypeptide are each set forth within the nucleotide sequence of SEQ ID NO:16.
Dependencies are inferred from the claim text.