Viral vectors for treating Parkinson's disease
AssigneeAmerican Gene Technologies International Inc.
InventorsTyler Lahusen, Charles David Pauza
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Abstract
A lentiviral vector system for expressing a lentiviral particle is disclosed. The lentiviral vector system includes a therapeutic vector, an envelope plasmid, and at least one helper plasmid. The lentiviral vector system can produce a lentiviral particle for inhibiting PARP expression in neuron cells of a subject afflicted with Parkinson's disease.
Claims15
A method of treating a subject suffering from Parkinson's disease, comprising administering to the subject a lentiviral particle that comprises:
- an envelope protein capable of infecting a cell in the subject;
- and
- a shRNA having at least 80% sequence identity with SEQ ID NO.:
- 6 or 7.
A method of decreasing poly(ADP-ribose) polymerase-1 (PARP-1) expression, comprising administering to a subject a lentiviral particle comprising:
- An envelope protein capable of infecting a cell in the subject;
- and
- A shRNA having at least 80% sequence identity with SEQ ID NO:
- 6 or 7.
Dependencies are inferred from the claim text.