Methods of using meloxicam for pain treatment and management
AssigneeViatris GmbH & Co. KG
InventorsSusanne Vogt, Jeffrey P. Smith, Kathleen Ocasio, Joachim Maus, Kristina Marschall, Matthew Hummel, Scott Haughie, Abhijit Deshmukh, Amit Antarkar
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Abstract
The present invention relates to a method for managing pain, such as acute pain, post-operative pain, or post-procedure pain, by administering meloxicam.
Claims29
A method of treating moderate to severe pain in an individual in need thereof comprising administering a solid oral meloxicam composition to the individual, wherein the composition comprises an amount of meloxicam or a pharmaceutically acceptable meloxicam salt equivalent to 15 mg meloxicam, the individual's pain before administration of the composition is at a level the same as an adult human reporting a pain level of about from 4.0 to about 10.0 on a pain NRS, and the time to the individual's first meaningful pain relief is about 5.5 hours or less following administration of the composition.
A method of treating moderate to severe pain in an individual in need thereof comprising administering a solid oral meloxicam composition to the individual, wherein the composition comprises 15 mg of meloxicam, and wherein the individual's pain about 48 hours from the time of administration of the composition is relieved by a degree corresponding to a 48-hour summed pain intensity difference (SPID0-48) of from about 163.0 to about 204.7 or from about 145.5 to about 180.7 using an 11-point NRS (zero to 10) for pain intensity.
A method of treating moderate to severe pain in an individual in need thereof comprising administering a solid oral meloxicam composition to the individual, wherein the composition comprises 15 mg of meloxicam, and wherein the composition provides a least squares mean summed pain intensity difference over 48 hours (least squares mean SPID0-48) using an 11-point pain NRS (zero to 10) in a population of clinical study subjects of from about 163.0 to about 204.7 or from about 145.5 to about 180.7.
Dependencies are inferred from the claim text.