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AssigneeJUVN3 Holdings, LLC
InventorsHector L. Lopez, Tim Ziegenfuss, Matthew Titlow
Estimating the term…
Compositions and methods are presented that that help reduce cellular ageing, improve cellular stress resilience, and/or promote increased longevity. Especially preferred compositions include a combination of a purine alkaloid, an isothiocyanate or thioglucoside, and a metal-containing antioxidant, where the purine alkaloid, the isothiocyanate or thioglucoside, and the metal-containing antioxidant may be chemically isolated compounds or extracts or other preparations from naturally occurring entities such as plants, bacteria, yeast, etc. Advantageously, contemplated compositions will be effective to reduce and repair oxidative stress, improve mitochondrial function, augment DNA repair and telomere maintenance, increase fatty acid metabolism, and modulate histone deacetylation.
A method of increasing telomere length in a cell of a mammal via SIRT1 and SIRT6 upregulation, comprising:
A method of increasing global SIRT 1-7 activity in a mammal, comprising:
A method of increasing at least one of the level of NAD+ or the ratio of NAD+/NADH via upregulation of PGC-1α, in a mammal, comprising:
Dependencies are inferred from the claim text.