Tartaric acid analogs and uses thereof
AssigneeTIM Therapeutics, Inc.
InventorsAnas M. Fathallah, Scott D. Larsen, Abdulraouf Ramadan
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Abstract
Provided herein are tartaric acid analogs represented by the following structural formula: or a pharmaceutically acceptable salt thereof, wherein values for the variables (e.g., A, R) are as described herein. Compounds of structural formula I and pharmaceutically acceptable salts thereof are believed to be useful in overcoming tumor resistance and promoting an immune response. Accordingly, also provided herein are various methods involving compounds of structural formula I, e.g., methods of treating a cancer in a subject in need thereof.
Claims16
A compound represented by the following structural formula:
- or a pharmaceutically acceptable salt thereof, wherein:
- A is *—OC(O)— or *—O(CH2)—;
- * indicates the point of attachment of A to R;
- R is (C2-C8)alkyl or (C2-C8)alkenyl substituted with one or more groups independently selected from (C6-C15)aryl or (C5-C15)heteroaryl;
- and
- wherein each alkyl and alkenyl is optionally and independently further substituted with one or more fluoro, and each aryl and heteroaryl is optionally and independently substituted with one or more R2 independently selected from halo, (C1-C3)alkoxy, (C1-C3)haloalkoxy, (C1-C3)alkyl or (C1-C3)haloalkyl.
Dependencies are inferred from the claim text.