Tetrahydrocurcumin compositions, methods of making, and methods of using the same
AssigneeRenibus Therapeutics, Inc.
InventorsDonald Jeffrey Keyser, Alvaro F. Guillem, Bhupinder Singh, Richard A Zager
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Abstract
The present invention relates to novel tetrahydrocurcumin (THCu) compositions, novel methods of manufacturing, and methods of using these compositions for therapeutic applications. The novel synthetic pathway(s) result in THCu compositions that generally lack hexahydrocurcumin (HHC), and include an improved impurity profile with reduced additional species that are generally present in hydrogenated curcumin compositions.
Claims20
A parenteral composition comprising:
- a) tetrahydrocurcumin (THCu) according to the formula:
- b) polyethylene glycol (PEG), and
- c) a pharmaceutically acceptable excipient, wherein the composition lacks detectable amounts of hexahydrocurcumin (HHC) as indicated by no peak with a relative retention time (RTT) of 7.14-7.15 as determined by gas chromatography (GC).
A method of treating a disorder, wherein the method comprises administering to a patient in need thereof a pharmaceutical composition comprising tetrahydrocurcumin (THCu) according to the formula:
- and
- a pharmaceutically acceptable excipient, wherein the pharmaceutical composition lacks detectable amounts of hexahydrocurcumin (HHC) as indicated by no peak with a relative retention time of 7.14-7.15 as determined by GC.
Dependencies are inferred from the claim text.