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US 12,697,308 B2Granted
Thermostable lipid nanoparticle and methods of use thereof
AssigneeMerck Sharp & Dohme Corp.
InventorsAndrew Bett, Izzat T. Raheem, Jason W. Skudlarek
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Abstract
The present disclosure provides, among other things, a lipid nanoparticle adjuvant composition. The present disclosure provides pharmaceutical compositions that include a stable lipid nanoparticle adjuvant and human papillomavirus (HPV) virus-like particles (VLPs) of at least one type of human papillomavirus (HPV) selected from the group consisting of HPV types: 6, 11, 16, 18, 26, 31, 33, 35, 39, 45, 51, 52, 53, 55, 56, 58, 59, 66, 68, 73, and 82.
Claims2
A lipid nanoparticle comprising:
- (1) a PEG-lipid having the structure set forth in Formula II, wherein n is from 30-50;
- (2) a phospholipid having the structure set forth in Formula III or Formula IIIa;
- (3) the following cationic lipid:
- (13Z, 16Z)—N, N-dimethyl-3-nonyldocosa 13, 16-dien-1-amine;
- and
- (4) cholesterol.
3 more elements
Dependencies are inferred from the claim text.