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US 12,697,307 B2Granted
Compositions and methods related to megakaryocyte-derived extracellular vesicles
AssigneeSTRM.bio Incorporated
InventorJonathan Thon
Life of this patent
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Abstract
Disclosed herein are compositions and methods related to megakaryocyte-derived extracellular vesicles derived from human pluripotent stem cells, where the megakaryocyte-derived extracellular vesicles may be utilized for drug delivery and treating various diseases.
Claims12
A composition comprising:
- a plurality of megakaryocyte-generated extracellular vesicles (MkEVs) comprising a lipid bilayer membrane surrounding a lumen, wherein:
- a. the MkEV lumen comprises one or more nucleic acid molecules from the megakaryocytes selected from mRNA, tRNA, rRNA, siRNA, microRNA, regulating RNA, and non-coding and coding RNA;
- and,
- b. the lipid bilayer membrane comprises one or more proteins associated with or embedded within, wherein the one or more proteins are selected from CD21 and GPVI;
- and,
- C. the MkEVs are isolated from megakaryocytes derived from a human pluripotent stem cell (HPSC).
3 more elements
Dependencies are inferred from the claim text.