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US 12,697,044 B2Granted
Biosensors for the gastrointestinal tract
AssigneeEnterasense Limited
InventorsDonal Devery, Maria Chiara Di Carlo
Life of this patent
Estimating the term…
Abstract
A biosensor capsule having a generally cylindrical housing with a plurality of sensors including a radiation sensor including a radiation emitter and a radiation detector and at least one additional sensor. A processor uses data feeds from the radiation sensor and also from one more additional sensor of a different type. Additional sensors may be pressure or pH sensors to provide sensor signals to detect location along the GI tract in use. There may be a camera, and data derived from other sensors may be embedded in a video feed timeline. The capsule may have an asymmetric weight distribution to help keep sensing parts immersed in liquid.
Claims19
A biosensor system comprising:
- (a) biosensor comprising:
- a housing configured for insertion in a mammalian gastrointestinal GI tract;
- a plurality of sensors including:
- a first sensor comprising at least one radiation emitter arranged to emit radiation to the environment outside the housing and a radiation detector arranged to detect radiation from the environment, wherein the housing has at least one portion which is transparent to sensing radiation, and the first sensor is arranged to emit radiation through the housing to the environment outside the housing and to detect radiation from the environment through the transparent portion of the housing,
- at least one additional sensor for detection of a condition in the environment, wherein the at least one additional sensor comprises at least one pressure sensor providing pressure detection data,
- a drive circuit for controlling the sensors, and
- a data transmitter for transmission of detection data received by the plurality of sensors, and
- (b) a processor linked with the sensors for processing the detection data in combination to provide information about said biosensor environment, wherein the processor is configured to use said pressure detection data in combination with first sensor detection data to determine if the biosensor is lodged in the GI tract with a sensing channel obstructed and/or if the biosensor is going through a valve, and
- wherein the processor is configured to determine from said first sensor an indication of presence of a particular fluid according to determining an angle as an arctan of a wavelength difference divided by a difference in detected signal and comparing said determined angle with a threshold angle.
6 more elements
A biosensor system comprising:
- (a) biosensor comprising:
- a housing configured for insertion in a mammalian gastrointestinal GI tract;
- a plurality of sensors including:
- a first sensor comprising at least one radiation emitter arranged to emit radiation to the environment outside the housing and a radiation detector arranged to detect radiation from the environment, wherein the housing has at least one portion which is transparent to sensing radiation, and the first sensor is arranged to emit radiation through the housing to the environment outside the housing and to detect radiation from the environment through the transparent portion of the housing,
- at least one additional sensor for detection of a condition in the environment, wherein the at least one additional sensor comprises at least one pressure sensor providing pressure detection data,
- a drive circuit for controlling the sensors, and
- a data transmitter for transmission of detection data received by the plurality of sensors, and
- (b) a processor linked with the sensors for processing the detection data in combination to provide information about said biosensor environment, wherein the processor is configured to use said pressure detection data in combination with first sensor detection data to determine if the biosensor is lodged in the GI tract with a sensing channel obstructed and/or if the biosensor is going through a valve, and
- wherein the processor is configured to, using detection data from said first sensor, determine a proportion of fall in detected signal strength for one or more emitter wavelengths as a parameter in determining the severity value;
- and wherein the processor is configured to use different light wavelengths to distinguish new blood from old blood;
- and wherein the processor is configured to use a ratio of two wavelengths to indicate old blood and a ratio of different wavelengths to indicate fresh blood.
8 more elements
A biosensor system comprising:
- (a) biosensor comprising:
- a housing configured for insertion in a mammalian gastrointestinal GI tract;
- a plurality of sensors including:
- a first sensor comprising at least one radiation emitter arranged to emit radiation to the environment outside the housing and a radiation detector arranged to detect radiation from the environment, wherein the housing has at least one portion which is transparent to sensing radiation, and the first sensor is arranged to emit radiation through the housing to the environment outside the housing and to detect radiation from the environment through the transparent portion of the housing,
- at least one additional sensor for detection of a condition in the environment, wherein the at least one additional sensor comprises at least one pressure sensor providing pressure detection data,
- a drive circuit for controlling the sensors, and
- a data transmitter for transmission of detection data received by the plurality of sensors, and
- (b) a processor linked with the sensors for processing the detection data in combination to provide information about said biosensor environment, wherein the processor is configured to use said pressure detection data in combination with first sensor detection data to determine if the biosensor is lodged in the GI tract with a sensing channel obstructed and/or if the biosensor is going through a valve, and
- wherein the processor is configured to use pressure sensor detection data to estimate the extent of liquid surrounding the biosensor.
6 more elements
A biosensor system comprising:
- (a) biosensor comprising:
- a housing configured for insertion in a mammalian gastrointestinal GI tract;
- a plurality of sensors including:
- a first sensor comprising at least one radiation emitter arranged to emit radiation to the environment outside the housing and a radiation detector arranged to detect radiation from the environment, wherein the housing has at least one portion which is transparent to sensing radiation, and the first sensor is arranged to emit radiation through the housing to the environment outside the housing and to detect radiation from the environment through the transparent portion of the housing,
- at least one additional sensor for detection of a condition in the environment, wherein the at least one additional sensor comprises at least one pressure sensor providing pressure detection data,
- a drive circuit for controlling the sensors, and
- a data transmitter for transmission of detection data received by the plurality of sensors, and
- a processor linked with the sensors for processing the detection data in combination to provide information about said biosensor environment, wherein the processor is configured to use said pressure detection data in combination with first sensor detection data to determine if the biosensor is lodged in the GI tract with a sensing channel obstructed and/or if the biosensor is going through a valve, and
- wherein the processor is configured to use a pH-specific algorithm to calculate blood concentration;
- and wherein the processor is configured to select a blood concentration on the basis that a ratio of Red transmitted light to orange transmitted light in the range of 1 to 1.5 indicates a low concentration of blood, while a value in a range of 2 to 10 indicates a medium concentration of blood, and a value greater than 10 indicate a high concentration of blood.
7 more elements
Dependencies are inferred from the claim text.