Cancer detection based on four quadrant mapping and matrix analysis of image data

A diagnostic method of analyzing imaging data, the method comprising:

• storing, in a memory of a computing system, hybrid imaging data of a tissue sample;
• and
• generating, by a processor operatively coupled to the memory, a four quadrant plot based on the hybrid imaging data, wherein each point in the four quadrant plot corresponds to an image voxel of the tissue sample;
• generating, by the processor and based on the hybrid imaging data, a matrix of b-values and echo time (TE) values for each image voxel in the four quadrant plot;
• determining, by the processor, a change in apparent diffusion coefficient (ADC) as a function of TE and a change in T2 as a function of b-value based on the matrix;
• identifying, by the processor and based on the matrix, a plurality of eigenvalues for each image voxel;
• and
• determining, by the processor and based at least in part on the plurality of eigenvalues, whether each image voxel of the tissue sample is associated with cancerous tissue or non-cancerous tissue.