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US 12,693,293 B2Granted
Devices and methods for detection of viruses from exhaled breath
AssigneeNortheastern University
InventorsShadi Emam, Nian-Xiang Sun
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Abstract
Described herein is a sensor comprising a doped silicon layer, a graphene layer on the doped silicon layer, a molecularly imprinted polymer (MIP) layer on the graphene layer, and electrodes in operative arrangement with the MIP layer and configured to provide a signal indicative of resistance. The MIP layer is derived from a MIP monomer and functional monomer. Also described herein is a detector comprising a sensor described herein as well as methods of making and using the sensors and detectors, e.g., to detect an analyte, such as a virus.
Claims21
A sensor, comprising:
- a doped silicon layer having an etched surface;
- a graphene layer directly on the etched surface of the doped silicon layer;
- a molecularly imprinted polymer (MIP) layer derived from a MIP monomer and functional monomer, the MIP layer disposed on the graphene layer;
- and
- electrodes in operative arrangement with the MIP layer, and said electrodes configured to provide a signal indicative of a resistance of the sensor.
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A method of fabricating a sensor, comprising:
- etching a surface of a doped silicon layer;
- forming a graphene layer directly on the etched surface of the doped silicon layer;
- and
- forming a MIP layer derived from a MIP monomer and functional monomer on the graphene layer, comprising the steps of:
- incubating the functional monomer with a template molecule under conditions suitable to establish an interaction between the functional monomer and the template molecule, thereby forming a pre-polymerization complex;
- polymerizing the pre-polymerization complex and the MIP monomer;
- and
- removing the template molecule from the MIP layer.
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Dependencies are inferred from the claim text.