Automated oxygen-dependent blood function measurement systems and methods
AssigneeFlorida Atlantic University Board of Trustees
InventorE Du
Life of this patent
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Abstract
Micro-electrical impedance-based assay systems (μZASs) for real-time monitoring of cellular response to an environmental condition are disclosed herein. An example microfluidic device can include: a cell channel configured to receive a sample substance (e.g., a blood sample), at least one gas channel operatively coupled to the cell channel defining a controlled testing environment of the microfluidic device, and a plurality of microfluidic impedance sensors configured to obtain electrical impedance-based measurements with respect to the sample substance.
Claims18
A micro-electrical impedance-based assay system (μZAS) for real-time monitoring of cellular response to an environmental condition, the μZAS comprising:
- at least one microfluidic device comprising:
- a cell channel configured to receive a sample substance;
- a gas channel network comprising a plurality of gas channels, the gas channel network being operatively coupled to the cell channel, wherein the gas channel network comprises at least one valve and at least one gas cartridge defining a controlled testing environment of the at least one microfluidic device;
- and
- a plurality of microfluidic impedance sensors configured to obtain, via one or more detection electrodes, electrical impedance-based measurement values with respect to the sample substance, wherein the at least one microfluidic device is operatively coupled to a gravity driven flow module configured to generate a gravity-driven hydrostatic pressure difference to drive a flow of the sample substance through the at least one microfluidic device;
- and
- a measurement instrument operatively coupled to the at least one microfluidic device that is configured to control a testing environment of the at least one microfluidic device.
A micro-electrical impedance-based assay system (μZAS) for real-time monitoring of cellular response to an environmental condition comprising a plurality of microfluidic devices, each microfluidic device comprising:
- a cell channel configured to receive a sample substance;
- a gas channel network comprising a plurality of gas channels, the gas channel network being operatively coupled to the cell channel, wherein the gas channel network comprises at least one valve and at least one gas cartridge defining a controlled testing environment of each of the plurality of microfluidic devices;
- and
- a plurality of microfluidic impedance sensors configured to obtain electrical impedance-based measurements with respect to the sample substance, wherein:
- each microfluidic device is operatively coupled to a gravity driven flow module configured to generate a gravity-driven hydrostatic pressure difference to drive a flow of the sample substance through each respective microfluidic device, and
- the plurality of microfluidic devices is operatively coupled to a measurement instrument that is configured to control a testing environment of each microfluidic device.
Dependencies are inferred from the claim text.