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US 12,693,203 B2Granted
Magnetically coupled collecting system for flow cytometry and cell sorter systems
AssigneeCytek Biosciences, Inc.
InventorsBabak Honaryar, David Vrane, Peter Truong, Kuncheng Wang, Max Schwartz
Life of this patent
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Abstract
A collecting system with a magnetically coupled sample mover is provided for flow cytometry and cell sorter systems. The collecting system uses magnets in a driver carriage to control the position of other magnets in a follower carriage. The driver carriage can thereby control the position of the follower carriage without physically touching the follower carriage.
Claims26
A collecting system for flow cytometry and cell sorter systems, the collecting system comprising:
- a driver carriage including one or more driver magnet clusters mounted and fixed on a top side of the driver carriage, wherein each driver magnet cluster includes two or more driver magnets having one or more repelling driver magnets touching one or more attracting driver magnets, wherein the two or more driver magnets are strategically spread out within each driver magnet cluster to enable attracting forces and repelling forces to have adequate strength to perform proper pulling and proper pushing, respectively;
- a follower carriage including one or more follower magnet clusters mounted and fixed on a bottom side of the follower carriage, wherein each follower magnet cluster includes two or more follower magnets having one or more repelling follower magnets touching one or more attracting follower magnets, wherein the one or more driver magnet clusters are paired with the one or more follower magnet clusters to make one or more magnet cluster pairs, wherein at least one magnet cluster pair is mounted to have an offset between a follower magnet cluster and a driver magnet cluster of the magnet cluster pair, wherein the offset is configured to have an offset size that reduces a lag between the follower carriage and the driver carriage;
- and
- a microplate removably mounted on the follower carriage and configured to hold wells for receiving sorted biological cells.
1 more element
A flow cytometer system comprising:
- an excitation optics system configured to project light;
- and
- a fluidics system configured to receive the projected light from the excitation optics system, the fluidics system including a cell sorter system having a collecting system that includes
- a driver carriage including one or more driver magnet clusters mounted and fixed on a top side of the driver carriage, wherein each driver magnet cluster includes two or more driver magnets having one or more repelling driver magnets touching one or more attracting driver magnets, wherein the two or more driver magnets are strategically spread out within each driver magnet cluster to enable attracting forces and repelling forces to have adequate strength to perform proper pulling and proper pushing, respectively, and
- a follower carriage including one or more follower magnet clusters mounted and fixed on a bottom side of the follower carriage, wherein each follower magnet cluster includes two or more follower magnets having one or more repelling follower magnets touching one or more attracting follower magnets, wherein the one or more driver magnet clusters are paired with the one or more follower magnet clusters to make one or more magnet cluster pairs, wherein at least one magnet cluster pair is mounted to have an offset between a follower magnet cluster and a driver magnet cluster of the magnet cluster pair, wherein the offset is configured to have an offset size that reduces a lag between the follower carriage and the driver carriage.
2 more elements
A method comprising:
- sorting cells or particles of a test sample into different fluid streams;
- collecting the different fluid streams into one or more wells of a set of wells in a collection tray held by a microplate removably mounted on a follower carriage;
- and
- magnetically moving the collection tray to arrange one or more wells of another set of wells in the collection tray to be under the different fluid streams, wherein the magnetically moving is performed by a driver carriage in cooperation with the follower carriage, wherein the driver carriage includes one or more driver magnet clusters mounted and fixed on a top side of the driver carriage, wherein at least one driver magnet cluster is mounted to have an offset between a follower magnet cluster and the driver magnet cluster, wherein the offset is configured to have an offset size that reduces a lag between the follower carriage and the driver carriage, wherein each driver magnet cluster includes two or more driver magnets having one or more repelling driver magnets touching one or more attracting driver magnets, wherein the two or more driver magnets are strategically spread out within each driver magnet cluster to enable attracting forces and repelling forces to have adequate strength to perform proper pulling and proper pushing, respectively.
1 more element
Dependencies are inferred from the claim text.