Engineered autotrophic bacteria for CO2 conversion to organic materials
AssigneeYeda Research and Development Co. Ltd.
InventorsRon Milo, Shmuel Gleizer, Niv Antonovsky, Elad Noor, Arren Bar-Even, Yehudit Zohar, Roee Ben Nissan, Elad Herz, Yinon Moise Bar-On
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Abstract
A recombinant bacteria which is genetically modified to express formate dehydrogenase (FDH), phosphoribulokinase (prk) and Ribulose-Bisphosphate Carboxylase/oxygenase (RuBisCo) is disclosed. The bacteria may be modified to be autotrophic.
Claims9
A population of recombinant bacteria which is genetically modified to express formate dehydrogenase (FDH), phosphoribulokinase (prk) and Ribulose-Bisphosphate Carboxylase/oxygenase (RuBisCo), wherein the recombinant bacteria is E. Coli, wherein the bacteria is capable of autotrophic growth following a culturing protocol which comprises:
- (a) culturing said bacteria in a medium comprising a pentose or hexose sugar;
- and subsequently
- (b) reducing the amount of said pentose or hexose sugar in said medium and increasing the amount of formate in said medium.
Dependencies are inferred from the claim text.