Variant ICOS ligand immunomodulatory proteins and related compositions and methods
AssigneeAlpine Immune Sciences, Inc.
InventorsLawrence Evans, Michael Kornacker, Ryan Swanson
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Abstract
Provided herein are immunomodulatory proteins comprising ICOSL variants and nucleic acids encoding such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of immunological and oncological conditions. Compositions and methods for making and using such proteins are provided.
Claims6
A nucleic acid molecule encoding a variant ICOSL-Fc fusion protein comprising a variant ICOSL polypeptide linked via a linker to an Fc region, wherein the variant ICOSL polypeptide is set forth in SEQ ID NO:565, the linker is set forth in SEQ ID NO:229, and the Fc region is set forth in SEQ ID NO:637.
Dependencies are inferred from the claim text.