Back to results
US 12,692,297 B2Granted
Engineered regulatory T cell
AssigneeUCL Business PLC
InventorsHans Stauss, Sharyn Thomas, Olivier Preham
Life of this patent
Estimating the term…
Abstract
The present invention relates to an engineered regulatory T cell (Treg) comprising a T cell receptor (TCR) which is capable of specifically binding to a myelin basic protein (MBP) peptide or variant or fragment thereof when the peptide is presented by a major histocompatibility complex (MHC) molecule. The present invention further relates to methods for providing an engineered Treg and to methods and uses of said engineered Treg and vectors and kits of vectors encoding said Treg.
Claims8
An engineered Treg comprising a T cell receptor (TCR), wherein the TCR comprises an α chain and a β chain,
- wherein the α chain of the TCR comprises three CDRs having the following amino acid sequences:
- CDR1α-
- (SEQ ID NO:
- 3)
- TISGTDY
- CDR2α-
- (SEQ ID NO:
- 4)
- GLTSN
- CDR3α-
- (SEQ ID NO:
- 1)
- TVYGGATNKLI;
- and
- wherein the β chain of the TCR comprises three CDRs having the following amino acid sequences:
- CDR1β-
- (SEQ ID NO:
- 5)
- DFQATT
- CDR2β-
- (SEQ ID NO:
- 6)
- SNEGSKA
- CDR3β-
- (SEQ ID NO:
- 2)
- SARGGSYNSPLH,
- wherein the α chain of the TCR comprises a human constant region amino acid sequence having at least 95% sequence identity to SEQ ID NO:
- 26 and/or the β chain of the TCR comprises a human constant region amino acid sequence having at least 95% sequence identity to SEQ ID NO:
- 27.
27 more elements
Dependencies are inferred from the claim text.