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US 12,692,293 B2Granted
Agrin polypeptide and uses thereof
AssigneeQueen Mary University of London
InventorsFrancesco Dell 'Accio, Suzanne Elizabeth Ruane
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Abstract
The present invention relates to novel polypeptides, which are derived from a human agrin or a variant of a human agrin. The invention also concerns uses of the polypeptides and compositions comprising the polypeptides.
Claims14
A soluble polypeptide comprising the amino acid sequence of SEQ ID NO:
- 3 or a variant thereof having at least 98% sequence identity to SEQ ID NO:
- 3,
- wherein the soluble polypeptide is a fragment of human agrin or a variant of human agrin and consists of up to 900 consecutive amino acids of said human agrin or said variant of human agrin;
- and
- wherein the soluble polypeptide has the ability to induce chondrocyte differentiation and/or chondrogenesis.
2 more elements
Dependencies are inferred from the claim text.