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AssigneesShanghai Institute of Materia Medica Chinese Academy of Science, Suzhou Qingya Qirui Biotechnology Co., Ltd.
InventorsJianhua Shen, Zhiyuan Zhu, Xiaomei Li, Kai Wang, Jia Liu
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Disclosed in the present invention are a lignan derivative, a preparation method therefor and the use thereof. The structure of the lignan derivative is as shown in a formula I, wherein in the formula, the definition of each substituent is as described in the description and claims. The lignan derivative of the present invention can be used as an inhibitor of mitochondrial respiratory chain complex I to inhibit mitochondrial oxidative phosphorylation and ATP generation, and can also be used for preventing and/or treating diseases associated with the elevated activity or expression of the mitochondrial respiratory chain complex I or enhanced mitochondrial oxidative phosphorylation.
A compound represented by formula I, or an enantiomer, diastereomer, racemic mixture, deuterated compound or pharmaceutically acceptable salt thereof,
A compound, or an enantiomer, diastereomer, racemic mixture, deuterated compound or pharmaceutically acceptable salt thereof, wherein the compound is selected from the group consisting of
Dependencies are inferred from the claim text.