Aroyl substituted tricyclic compound, preparation method therefor and use thereof

A compound of formula (C), a pharmaceutically acceptable salt thereof, a stereoisomer thereof, or a solvate thereof:

• in the formula,
• R1 and R2 are each independently selected from:
• H, C1-6 alkoxy and C1-6 thioalkyl;
• or R1 and R2 combining with the carbon atoms to which they are attached form:
• C═O or C═S;
• the C1-6 alkoxy and the C1-6 thioalkyl are each independently unsubstituted or substituted by 1, 2, 3 or 4 substituents independently selected from group S1;
• R3 and R4 are each independently selected from:
• C1-6 alkyl and C3-6 monocyclic cycloalkyl;
• or R3 and R4 combining with the carbon atoms to which they are attached form:
• C3-6 monocyclic cycloalkyl or 3- to 6-membered monocyclic heterocyclyl, the 3- to 6-membered monocyclic heterocyclyl has 1 or 2 heteroatoms selected from N and O as ring atoms;
• wherein C1-6 alkyl, C3-6 monocyclic cycloalkyl and 3- to 6-membered monocyclic heterocyclyl are each independently unsubstituted or substituted by 1, 2, 3 or 4 substituents independently selected from group S1;
• n is 0;
• E is NR5, O or N;
• R5 is H, C1-6 alkyl, deuterated C1-6 alkyl, —C1-4 alkylene-hydroxy, —C1-4 alkylene-C1-6 alkoxy or —C1-4 alkylene-NRaRb;
• when E is NR5 or O, “” connected with E represents a single bond;
• when E is N, “” connected with E represents a double bond and R2 is absent;
• A is CR6 or N;
• wherein, R6 is H;
• B is CR7;
• wherein, R7 is H;
• G1 is C6-14 aryl or 5- to 6-membered monocyclic heteroaryl;
• the 5- to 6-membered monocyclic heteroaryl has 1 or 2 heteroatoms selected from N, O and S as ring atoms, and the C6-14 aryl and the 5- to 6-membered monocyclic heteroaryl are unsubstituted or substituted by 1, 2, 3 or 4 substituents independently selected from group S2;
• G2 is C6-14 aryl or 5- to 6-membered monocyclic heteroaryl;
• the 5- to 6-membered monocyclic heteroaryl has 1 or 2 heteroatoms selected from N, O and S as ring atoms, and the C6-14 aryl and the 5- to 6-membered monocyclic heteroaryl are unsubstituted or substituted by 1, 2, 3 or 4 substituents independently selected from group S2;
• L is CR8R9 or O;
• wherein, R8 and R9 are each independently H;
• i is 0 or 1;
• substituents in the group S1 are selected from:
• deuterium, halogen, cyano, hydroxyl, C1-6 alkyl, C1-6 alkoxy, halo C1-6 alkoxy, deuterated C1-6 alkoxy, —C1-4 alkylene-hydroxy, —C(O)C1-6 alkyl, —C(O)C3-6 monocyclic cycloalkyl, 3- to 6-membered monocyclic heterocyclyl, —O—C3-6 monocyclic cycloalkyl, —NRaRb and —ORc, wherein the 3- to 6-membered monocyclic heterocyclyl has 1 or 2 heteroatoms selected from N and O as ring atoms;
• substituents in the group S2 are selected from:
• halogen, cyano, C1-6 alkyl, halo C1-6 alkyl, deuterated C1-6 alkyl, C1-6 alkoxy, halo C1-6 alkoxy, deuterated C1-6 alkoxy, C3-6 monocyclic cycloalkyl, halo C3-6 monocyclic cycloalkyl, —O—C3-6 monocyclic cycloalkyl, —NRaRb and —ORc;
• Ra and Rb are each independently C1-6 alkyl;
• Rc is —C1-4 alkylene-C1-6 alkoxy or C3-6 monocyclic cycloalkyl substituted by 1 or 2 halogens;
• a carbon atom marked at “*” is a chiral carbon atom or an achiral carbon atom.