Tetrahydroisoquinoline derivatives for the treatment of red blood disorders and inflammatory diseases

A compound of Formula (I):

• or a pharmaceutically acceptable salt thereof, wherein:
• R is H or C1-6alkyl optionally substituted with one substituent selected from —OH, C1-6 alkyloxy, or C6-12 aryl;
• R1 is H or C1-6 alkyl;
• R2 is H or C1-6 alkyl;
• R3 is H or C1-6 alkyl;
• Ring B is C6-12 arylene or C3-12 heteroarylene containing 1 to 4 heteroatoms independently selected from N and O provided that Ring B is not
• wherein the * designates a bond to L;
• n is 0, 1, 2, or 3;
• each R5 is independently halo, C1-6 alkyl, or C1-6 alkyloxy;
• Ring A is C6-12 arylene or C3-12 heteroarylene containing 1-2 heteroatoms independently selected from N and O;
• m is 1, 2, 3, or 4;
• each R4 is independently H, halo, C1-6 alkyl, or C1-6 alkoxy, wherein the C1-6 alkyl and C1-6 alkoxy groups are optionally substituted with 1-3 groups independently selected from halo, C1-6 alkyloxy, amido, and N,N-dimethylamido groups;
• and
• L is C4-8 alkylene, C4-8 alkenylene, C4-8 heteroalkylene, or C4-8 heteroalkenylene, each of which is optionally substituted with 1 or 4 groups independently selected from halo and C1-6 alkyl, and wherein the heteroalkylene and heteroalkenylene comprise 1 to 4 oxygen atoms.