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US 12,692,254 B2Granted
Benzimidazole inhibitors of PAD enzymes
OwnerKhehyong Nguinventor
Life of this patent
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Abstract
The present invention provides compounds of Formula (I): or a pharmaceutically acceptable salt thereof, useful as inhibitors of PAD4, compositions thereof, and methods of treating PAD4-related disorders. Variables rings A, B, R1, R3, R8, and other variables are as defined herein.
Claims3
A compound having Formula (III):
- or a pharmaceutically acceptable salt thereof, wherein:
- is selected from
- Q is selected from N and CH;
- R2 is selected from CH3 and —CH2-cyclopropyl;
- R3 is —OC1-4 alkyl;
- R4, at each occurrence, is selected from Cl and —OC1-3 alkyl;
- R6 is selected from
- R7, at each occurrence, is independently selected from H, F, Cl, Br, CN, C1-4alkyl, —S(═O)pRc, C(═O)Rb, —C(═O)ORb, C(═O)NRaRa, —ORb, and C3-6cycloalkyl;
- Ra, at each occurrence, is independently selected from H and C1-6 alkyl substituted with 0-5 Re;
- Rb, at each occurrence, is independently selected from H and C1-6 alkyl substituted with 0-5 Re;
- Rc is C1-6 alkyl substituted with 0-5 Re;
- Re, at each occurrence, is independently selected from F, Cl, Br, CN, and C1-6 alkyl;
- n, at each occurrence, is independently selected from zero and 1;
- and
- p, at each occurrence, is independently selected from zero, 1, and 2.
12 more elements
Dependencies are inferred from the claim text.