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US 12,692,236 B2Granted
Small molecule modulators of sigma-1 and sigma-2 receptors and uses thereof
AssigneeNorthwestern University
InventorsGary E. Schiltz, Iredia D. Iyamu, Rama K. Mishra, Wei Lv, Neha Malik
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Abstract
This invention is in the field of medicinal chemistry. In particular, the invention relates to anew class of small-molecules having a tetrahydroindazole structure which function as modulators (e.g., activators or inhibitors) of sigma-1 and/or sigma-2 receptors, and their use as therapeutics for the treatment of cancer and other diseases (e.g., neurological conditions) characterized with sigma-1 and/or sigma-2 receptor activity.
Claims7
A compound described by Formulas I, II, III, IV, V, or VI:
- including pharmaceutically acceptable salts, solvates, and/or prodrugs thereof;
- wherein X is either CH or Nitrogen;
- wherein R1 is selected from
- wherein R2 is selected from Hydrogen,
- wherein R3 is selected from
- wherein R4 is Hydrogen or methyl;
- wherein if the compound is described by Formula I
- then R2 cannot be
5 more elements
A compound selected from the group consisting of:
- or a pharmaceutically acceptable salt, solvate, or prodrug thereof, and a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.