Fused ring compound and application thereof

A fused ring compound represented by formula I, a pharmaceutically acceptable salt thereof, a stereoisomer thereof, a tautomer thereof, an isotopic compound thereof, a crystal form thereof, a nitrogen oxide thereof, a solvate thereof or a solvate of the pharmaceutically acceptable salt thereof;

• wherein,
• is a single bond or a double bond;
• is benzene ring, 6-membered heteroaromatic ring having one or two heteroatoms N or 6-membered heterocycloalkene having one heteroatom N;
• is benzene ring;
• R1 is
• R1-1 is halogen, hydroxyl, amino, —NHR1-1-4, —N(R1-1-5)(R1-1-6), C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 alkyl substituted by one or more R1-1-1, C3-C6 cycloalkyl substituted by one or more R1-1-2, or, “4- to 7-membered heterocycloalkyl with 1, 2 or 3 heteroatoms selected from one or more of N, O and S” substituted by one or more R1-1-3;
• R1-1-1, R1-1-2, R1-1-3, R1-1-4, R1-1-5 and R1-1-6 are independently halogen, hydroxyl, C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 alkoxy or “4- to 7-membered heterocycloalkyl with 1, 2 or 3 heteroatoms selected from one or more of N, O and S”;
• R3 is
• n is 0, 1, 2 or 3;
• R3-1 is independently halogen, cyano, hydroxyl, C1-C6 alkyl, C1-C6 alkoxy, C3-C6 cycloalkyl, C1-C6 alkyl substituted by one or more R3-1-1, C1-C6 alkoxy substituted by one or more R3-1-2, or C1-C6 alkoxy substituted by C1-C6 alkoxy;
• R3-1-1 and R3-1-2 are independently halogen;
• R3-2 is C3-C6 cycloalkyl substituted by one or more R3-2-1, “5- to 6-membered heterocycloalkyl with 1, 2 or 3 heteroatoms selected from one or more of N, O and S” substituted by one or more R3-2-2, “7- to 8-membered heterocycloalkyl with 1, 2 or 3 heteroatoms selected from one or more of N, O and S” substituted by one or more R3-2-2 or “5- to 6-membered heteroaryl with 1, 2 or 3 heteroatoms selected from one or more of N, O and S” substituted by one or more R3-2-3;
• R3-2-1, R3-2-2 and R3-2-3 are independently halogen, hydroxyl, C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 alkoxy, or, C1-C6 alkoxy substituted by C1-C6 alkoxy;
• m is 0, 1, 2, 3 or 4;
• R2 is oxo, halogen, cyano, isocyano, amino, C1-C10 alkyl, C1-C10 alkyl substituted by one or more R2-1, C2-C10 alkenyl, C2-C10 alkenyl substituted one or more R2-26, C2-C10 alkynyl, C2-C10 alkynyl substituted by one or more R2-27, C3-C6 cycloalkyl, C3-C6 cycloalkyl substituted by one or more R2-3, “5- to 6-membered heterocycloalkyl with 1, 2 or 3 heteroatoms selected from one or more of N, O and S”, “3- to 4-membered heterocycloalkyl with 1 or 2 heteroatoms selected from one or more of N, O and S”, phenyl, phenyl substituted by one or more R2-4, “5- to 6-membered heteroaryl with 1, 2 or 3 heteroatoms selected from one or more of N, O and S”, “5- to 6-membered heteroaryl with 1, 2 or 3 heteroatoms selected from one or more of N, O and S” substituted by one or more R2-5, —(C═O)—R2-2, —OR2-6, —C(═O)OR2-7, —NR2-8R2-9, “5- to 6-membered heterocycloalkyl with 1, 2 or 3 heteroatoms selected from one or more of N, O and S” substituted by one or more R2-10, “3- to 4-membered heterocycloalkyl with 1 or 2 heteroatoms selected from one or more of N, O and S” substituted by one or more R2-10, —C(═O)NHR2-11, —C(═O)NR2-12R2-13, —NR2-14C(═O)R2-1, —NR2-16S(═O)2R2-17, —NR2-18S(═O)R2-19, —S(═O)2NHR2-20, —S(═O)NHR2-21, —S(═O)2NR2-22R2-23, —S(═O)2R2-24 or —S(═O)R2-25;
• R2-1 is independently halogen, hydroxyl, C3-C6 cycloalkyl, C3-C6 cycloalkyl substituted by one or more R2-1-8, “4- to 6-membered heterocycloalkyl with 1, 2 or 3 heteroatoms selected from one or more of N, O and S”, “4- to 6-membered heterocycloalkyl with 1, 2 or 3 heteroatoms selected from one or more of N, O and S” substituted by one or more R2-17, phenyl, phenyl substituted by one or more R2-1-1, “5- to 6-membered heteroaryl with 1, 2 or 3 heteroatoms selected from one or more of N, O and S”, “5- to 6-membered heteroaryl with 1, 2 or 3 heteroatoms selected from one or more of N, O and S” substituted by one or more R2-1-6, —OR2-1-2, —N(R2-1-3)(R2-1-4), or, —S(═O)2R2-1-5;
• R2-1-1, R2-1-6, R2-1-7 and R2-1-8 are independently oxo, hydroxyl, amino, carboxyl, halogen, —CN, C1-C6 alkyl, C1-C6 alkyl substituted by one or more halogen, —OR2-1-1, or, —N(R2-1-1-2)(R2-1-1-3);
• R2-1-1-1, R2-1-1-2 and R2-1-1-3 are independently C1-C6 alkyl;
• R2-1-2 is independently C1-C6 alkyl or C3-C6 cycloalkyl;
• R2-1-3 and R2-1-4 are independently hydrogen, C1-C6 alkyl or C3-C6 cycloalkyl;
• R2-1-5 is independently C1-C6 alkyl or C3-C6 cycloalkyl;
• R2-3 is independently C1-C6 alkyl;
• R2-4 and R2-5 are independently halogen, hydroxyl, C1-C6 alkyl, C1-C6 alkyl substituted by one or more R2-4-3, —N(R2-4-1)(R2-4-2) or C1-C6 alkoxy;
• R2-4-1 and R2-4-2 are independently hydrogen, C1-C6 alkyl or C3-C6 cycloalkyl;
• R2-4-3 is halogen;
• R2-2 is C1-C6 alkyl, C3-C6 cycloalkyl, phenyl, C1-C6 alkyl substituted by one or more R2-2-2, or, phenyl substituted by one or more R2-2-1;
• R2-2-1 is independently halogen;
• R2-2-2 is independently halogen;
• R2-6 is hydrogen, C1-C10 alkyl, C1-C10 alkyl substituted by one or more R2-6-1, C3-C6 cycloalkyl, C6-C10 aryl, C6-C10 aryl substituted by one or more R2-6-2, “3- to 6-membered heterocycloalkyl with 1, 2 or 3 heteroatoms selected from one or more of N, O and S” or, “3- to 6-membered heterocycloalkyl with 1, 2 or 3 heteroatoms selected from one or more of N, O and S” substituted by one or more R2-6-3;
• R2-6-1 is independently oxo, halogen, hydroxyl, amino, carboxyl, —CN, C1-C6 alkyl, C1-C6 alkyl substituted by one or more halogen, C1-C6 alkoxy, C3-C6 cycloalkyl, C6-C10 aryl, C6-C10 aryl substituted by one or more R2-6-1-1, —OR2-6-1-2 or —N(R2-6-1-3)(R2-6-1-4);
• R2-6-2 is independently halogen, C1-C6 alkyl or C1-C6 alkoxy;
• R2-6-3 is independently —C(═O)—C1-C6 alkyl;
• R2-6-1-1 is independently halogen;
• R2-6-1-2, R2-6-1-3 and R2-6-1-4 are independently C1-C6 alkyl;
• R2-7 is C1-C6 alkyl, C3-C6 cycloalkyl or phenyl;
• R2-8 and R2-9 are independently hydrogen, C1-C6 alkyl, C6-C10 aryl, or C6-C10 aryl substituted by one or more R2-8-1;
• R2-8-1 is halogen or C1-C6 alkoxy;
• R2-10 is independently C1-C6 alkyl or oxo;
• R2-26 and R2-27 are independently halogen or C1-C6 alkyl;
• R2-11, R2-12, R2-13, R2-14, R2-15, R2-16, R2-17, R2-18, R2-19, R2-20, R2-21, R2-22, R2-23, R2-24 and R2-2 are independently C1-C6 alkyl, C1-C6 alkoxy, C3-C6 cycloalkyl, “5- to 6-membered heterocycloalkyl with 1, 2 or 3 heteroatoms selected from one or more of N, O and S”, phenyl, phenyl substituted by one or more R2-11-1, “5- to 6-membered heteroaryl with 1, 2 or 3 heteroatoms selected from one or more of N, O and S”, or “5- to 6-membered heteroaryl with 1, 2 or 3 heteroatoms selected from one or more of N, O and S” substituted by one or more R2-11-2;
• R2-11-1 and R2-11-2 are independently halogen, cyano, hydroxyl, C1-C6 alkyl, C1-C6 alkoxy or C3-C6 cycloalkyl;
• R2 is located on