Filter holder for extrusion of liposomes

A filter holder for liposome extrusion, the filter holder comprising:

• a housing defining a longitudinal center axis, the housing including an inlet extending from an inlet cavity and an outlet extending from an outlet cavity;
• and
• a filter support member disposed within the housing between the inlet cavity and the outlet cavity, the filter support member including:
• an upstream side adjacent the inlet cavity, the upstream side having a filter support surface configured to support a membrane filter assembly,
• a downstream side adjacent the outlet cavity and opposite the upstream side, and
• a plurality of passages extending through the filter support member from the upstream side to the downstream side,
• wherein the filter holder is configured such that the material to be extruded flows through the membrane filter assembly and into the outlet cavity via the plurality of passages before being discharged through the outlet;
• and
• wherein the filter support member includes a plurality of interconnected channels formed in the downstream side of the filter support member.

An extrusion system comprising:

• a supply reservoir containing material to be extruded;
• a pressure source configured to pressurize material to be extruded drawn from the reservoir;
• a filter holder including
• a housing having an inlet configured to receive the pressurized material to be
• extruded and an outlet configured to discharge an extrudate,
• a membrane filter assembly disposed between the inlet and the outlet,
• a filter support member disposed within the housing, the filter support member including:
• an upstream side having a filter support surface configured to support the membrane filter assembly,
• a downstream side opposite the upstream side, the downstream side including a first recess, and
• a plurality of passages extending through the filter support member from the filter support surface to the first recess, and
• an outlet cavity at least partially defined by the first recess, the outlet cavity in fluid communication with the outlet;
• and
• a collection reservoir configured to receive the extrudate from the outlet of the filter holder;
• and
• wherein the filter support member includes a plurality of interconnected channels formed in the downstream side of the filter support member.

A filter holder for liposome extrusion, the filter holder comprising:

• a housing including an inlet configured to receive a material to be extruded and an outlet;
• a filter support member disposed within the housing between the inlet and the outlet, the filter support member including:
• an upstream side having a filter support surface configured to support a membrane filter assembly,
• a downstream side opposite the upstream side, and
• a plurality of passages extending through the filter support member from the filter support surface to the downstream side;
• and
• an outlet cavity in fluid communication with the outlet,
• wherein the filter holder is configured such that the material to be extruded flows through the membrane filter assembly and into the outlet cavity via the plurality of passages before being discharged through the outlet;
• wherein the filter support member includes a circumferential groove;
• and
• wherein the filter holder further comprises a temperature regulating assembly configured to circulate a heat transfer fluid through the circumferential groove.

A filter holder for liposome extrusion, the filter holder comprising:

• a housing defining a longitudinal center axis, the housing including an inlet extending from an inlet cavity and an outlet extending from an outlet cavity;
• and
• a filter support member disposed within the housing between the inlet cavity and the outlet cavity, the filter support member including:
• an upstream side adjacent the inlet cavity, the upstream side having a filter support surface configured to support a membrane filter assembly,
• a downstream side adjacent the outlet cavity and opposite the upstream side, and
• a plurality of passages extending through the filter support member from the upstream side to the downstream side,
• wherein the filter holder is configured such that the material to be extruded flows through the membrane filter assembly and into the outlet cavity via the plurality of passages before being discharged through the outlet;
• wherein the filter support member includes a circumferential groove;
• and
• wherein the filter holder further comprises a temperature regulating assembly configured to circulate a heat transfer fluid through the circumferential groove.