Diffusion transfer functionalized membrane
AssigneeWisconsin Alumni Research Foundation
InventorsMark Raymond Etzel, Na Li
Life of this patent
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Abstract
A method of making a filter, the resulting filter, and a method of using the filter to filter proteins from solution are described. The method includes contacting a porous, polymeric substrate with a transfer liquid comprising a solvent(s) and a charged polymeric solute. The transfer liquid and the polymeric substrate have a Hansen Solubility Parameter (“HSP”) distance of from about 10 to about 35. Contacting the polymeric substrate with the transfer solution causes the polymeric substrate to accept the charged polymeric solute by diffusion transfer, thereby yielding a functionalized filter medium. Removal of the transfer liquid from the polymeric substrate traps the charged polymeric solute on the surface of the polymeric substrate.
Claims16
A filter medium made by a method comprising:
- (a) contacting a raw unmodified porous, polymeric substrate with a transfer liquid comprising at least one solvent and a charged polymeric solute, wherein the transfer liquid and the polymeric substrate have a Hansen Solubility Parameter (“HSP”) distance of from about 10 to about 35, for a time and at a temperature wherein at least a portion of the charged polymeric solute diffuses into the polymeric substrate;
- and then
- (b) removing the transfer liquid from the polymeric substrate to trap the portion of the charged polymeric solute that diffuses into the polymeric substrate in step (a) on the surface of the polymeric substrate;
- wherein the polymeric substrate, when contacted with the transfer liquid, is a raw unmodified polymeric substrate.
Dependencies are inferred from the claim text.