High-porosity nanofiber nonwovens as a support structure for stromal tissue
AssigneeFraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.
InventorsTobias Weigel, Florian Groeber-Becker, Jan Hansmann, Bastian Christ, Jörn Probst
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Abstract
The present invention relates to nanofiber nonwovens comprising a network of nanofibers, which are composed of at least one nanofiber material and which enclose pores, to methods for producing nanofiber nonwovens, to the use thereof as well as to artificial tissue comprising these nanofiber nonwovens and methods for producing these artificial tissues.
Claims22
A nanofibre nonwoven comprising a network of nanofibres (7) composed of at least one nanofibre material and enclosing pores (5), produced by a method comprising the method steps:
- a) providing at least one nanofibre material and at least one porogen material suitable for formation of at least one porogen,
- b) electrospinning the at least one nanofibre material while introducing at least one porogen (6) formed from the at least one porogen material and the porogen having a diameter of 30 to 1000 μm, so that the volume ratio of porogen material to nanofibre material in the electrospun nanofibre nonwoven obtained after completion of this method step is 40:99 to 60:1 based on a total volume of fibres and porogens of a nanofibre nonwoven), wherein the at least one nanofibre material is present in a form of nanofibre layers, wherein a pore is space enclosed by nanofibre layers which can be filled by porogens, cells or fluids, wherein the pores spatially separate the individual nanofibre layers from each other, wherein a nanofibre layer is a layer of nanofibres arranged above and/or next to one another, wherein, insofar as the porogen is provided in method step a) as a ready-formed porogen, in method step b) an introducing of the porogen and the electrospinning of the nanofibre material is carried out alternately, or insofar the porogen material provided in method step a) is a material suitable for forming at least one fibrous porogen in method step b) at least one fibrous porogen is formed from the porogen material before or during its introduction into the electrospun nanofibre material;
- and
- c) obtaining the nanofibre nonwoven comprising at least one porogen (6).
A method for producing a nanofibre nonwoven comprising a network of nanofibres (7) composed of at least one nanofibre material and enclosing pores (5), comprising the following method steps:
- a) providing at least one nanofibre material and at least one porogen material suitable for formation of at least one porogen,
- b) electrospinning the at least one nanofibre material while introducing at least one porogen (6) formed from the at least one porogen material and the porogen having a diameter of 30 to 1000 μm, so that the volume ratio of porogen material to nanofibre material in the electrospun nanofibre nonwoven obtained after completion of this method step is 40:9940 to 99 to 60:160 to 1 (in each case volume based on a total volume of, i.e. fibres and porogens of a nanofibre nonwoven), wherein the at least one nanofibre material is present in a form of nanofibre layers, wherein a pore is space enclosed by nanofibre layers which can be filled by porogens, cells or fluids, wherein the pores spatially separate the individual nanofibre layers from each other, wherein a nanofibre layer is a layer of nanofibres arranged above and/or next to one another, wherein, insofar as the porogen is provided in method step a) as a ready-formed porogen, in method step b) an introducing of the porogen and the electrospinning of the nanofibre material is carried out alternately, or insofar the porogen material provided in method step a) is a material suitable for forming at least one fibrous porogen in method step b) at least one fibrous porogen is formed from the porogen material before or during its introduction into the electrospun nanofibre material;
- c) obtaining the nanofibre nonwoven comprising at least one porogen (6), in particular having a porosity of 90.0 to 99.9 vol. %, in particular 98.5 to 99.9 vol. % (in each case based on the total volume of the nanofibre nonwoven), preferably having a porosity of 90.0 to 99.9%, in particular 98.5 to 99.9 vol. % (in each case based on the total volume of the nanofibre nonwoven) and meshes (8) with a width of 10 to 200 μm2 (measured in water without porogen (6)).
Dependencies are inferred from the claim text.