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US 12,691,164 B2Granted
Polyethylene glycol lipid and use thereof
AssigneeJenkem Technology Co., Ltd. (Tianjin)
InventorsMeina Lin, Shuzhen Hu, Changyou Zhu, Qingbin Wang, Jie Wang, Hongli Jia, Xiaomeng Chen, Xuan Zhao
Life of this patent
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Abstract
A new typepolyethylene glycol lipid and the use thereof. The lipid is free of in-vivo cleavable bonds, and can deliver a bioactive substance to a target cell or organ more stably. In addition, the new typepolyethylene glycol lipid can be positively charged in a specific pH environment, and can more easily form stable particles with the bioactive substance, so that the bioactive substance plays a role in the target cell or organ.
Claims14
A polyethylene glycol lipid having a structure of formula I below:
- wherein R1 and R2 are identical or different long chain hydrocarbyl, and the long chain hydrocarbyl contains 11 to 17 carbon atoms;
- PEG is a polyethylene glycol chain;
- and
- L1, L2 and L3 are absent or are in-vivo non-cleavable linkers.
1 more element
Dependencies are inferred from the claim text.