Compositions and methods for treating diabetes
AssigneePoviva Corp.
InventorsJohn Docherty, Christopher Andrew Bunka
Life of this patent
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Abstract
Disclosed herein are compositions and methods for treating diabetes wherein the compositions comprise GLP-1 agonists. The disclosed compositions are also effective for reducing body weight and improving triglyceride and cholesterol levels. Disclosed herein are methods for treating type-2 diabetes in a subject, for lowering a subject's A1C, for lowering the body mass of a subject, and for regulating the incretin hormone levels of a subject.
Claims16
A method for treating type-2 diabetes in a subject comprising administering to a subject in need a composition comprising:
- a) from about 0.5% to about 20% by weight of one or more GLP-1 agonists;
- b) from about 0.5% to about 40% by weight of olive oil;
- c) from about 1.5% to about 65% by weight of a bile salt extract;
- d) from about 35% to about 65% by weight of sodium bicarbonate;
- and
- e) from about 15% to about 85% by weight of one or more carriers.
A method for treating type-2 diabetes in a subject comprising administering to a subject in need a composition comprising:
- a) from about 0.2 mg to about 25 mg of one or more GLP-1 agonists chosen from dulaglutide, exenatide, liraglutide, lixisenatide, semaglutide, and tirzepatide, or mixtures thereof;
- b) from about 0.4 mg to about 50 mg of olive oil;
- c) from about 0.05 mg to about 5 mg of a bile salt extract wherein the bile salts are an extract containing from about 45% to about 55% by weight of cholic acid, deoxycholic acid, taurocholate, and glycocholic acid, or mixtures thereof;
- d) from about 1 mg to about 460 mg of sodium bicarbonate;
- and
- e) from about 3 mg to about 480 mg of one or more carriers chosen from sodium N-[8-(2-hydroxybenzoyl)amino] caprylate (SNAC) gum Arabic, inulin, mannitol, silicon dioxide, colloidal silicon dioxide, microcrystalline cellulose, D-lactose monohydrate, tapioca starch, tapioca flour, and quillaia, or mixtures thereof.
Dependencies are inferred from the claim text.