Therapeutic carbon monoxide formulations
AssigneesThe Brigham and Women's Hospital, Inc., Massachusetts Institute of Technology, Beth Israel Deaconess Medical Center, Inc.
InventorsCarlo Giovanni Traverso, James D. Byrne, Hannah Boyce, Leo E. Otterbein, David J. Gallo
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Abstract
A pharmaceutical composition is described that includes a pharmaceutical carrier comprising gas pockets containing carbon monoxide gas, wherein the pharmaceutical carrier is a foam, a solid, or a hydrogel. Methods of using the pharmaceutical composition to treat an inflammatory disease or condition, and methods of making the pharmaceutical composition, are also described.
Claims25
A pharmaceutical composition, comprising a pharmaceutical carrier comprising gas pockets containing carbon monoxide gas having a concentration of at least 0.5 mg/g, as measured by gas-chromatography thermal conductivity, wherein the pharmaceutical carrier is a foam or a hydrogel comprising xanthan gum, methylcellulose and maltodextrin, wherein the ratio of methylcellulose to maltodextrin is from 0:6:1 to 1:1 w/w and the ratio of maltodextrin to xanthan gum is from 2.5:1 to 1.5 to 1, or a solid sugar matrix comprising glucose, fructose, sucrose, lactose, maltose, isomaltose, corn syrup or mixtures thereof.
Dependencies are inferred from the claim text.