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US 12,691,136 B2Granted
Metal compositions and methods of use thereof
AssigneeUniversity of Massachusetts
InventorsMingdi Yan, William Ndugire, Olof Ramstrom, N. G. Hasitha Raviranga
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Abstract
Compositions comprising metal entities in combination with an activating agent, or pharmaceutically acceptable salts thereof are disclosed. Certain compositions are active as antibacterial, antiviral, antifungal, anti-protozoal, and/or anti-worm agents. The disclosure provides pharmaceutical compositions containing the compositions. Methods of using the composition to treat bacterial infections are disclosed.
Claims17
A composition comprising:
- a metal entity and an activating agent, or pharmaceutically acceptable salts thereof, wherein:
- the composition comprises a synergistic amount of the activating agent and the metal entity;
- the activating agent comprises thiourea;
- and
- the metal entity comprises at least one of auranofin, gold nanoclusters, or a combination thereof, wherein the gold nanoclusters comprise at least one of Au101Mal, Au101Tre, Au101Glc, AuCitrate, Au18SG14, Au22SG18, Au25SG18, Au101TPPMS, Au(TPPMS)2, [AuTPPMS]Cl, [Au9(TPPMS)8]Cl3, Au101(TPPMS)21Cl5, HAuCl4(Au3+), Au101(TPPMS)19(Ac4Glc)2Cl5, Au101(TPPMS)14(Ac4Glc)7Cl5, Au101(TPPMS)11(Ac4Glc)10C15, Au101(TPPMS)7(Ac4Glc)14Cl5, or a combination thereof.
2 more elements
A composition comprising:
- an activating agent that comprises a thiourea;
- and
- a metal compound comprising auranofin or gold nanoclusters, wherein the gold nanoclusters comprise Au101Mal, Au101Tre, Au101Glc, AuCitrate, Au18SG14, Au22SG18, Au25SG18, Au101TPPMS, Au(TPPMS)2, [AuTPPMS]Cl, [Au9(TPPMS)8]Cl3, Au101(TPPMS)21Cl5, HAuCl4(Au3+), Au101(TPPMS)19(Ac4Glc)2Cl5, Au101(TPPMS)14(Ac4Glc)7Cl5, Au101(TPPMS)11(Ac4Glc)10Cl5, or Au101(TPPMS)7(Ac4Glc)14Cl5, wherein the composition comprises a synergistic amount of the activating agent and the metal compound.
Dependencies are inferred from the claim text.