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US 12,691,135 B2Granted
Inhibitors of micro-RNA 22
AssigneesBeth Israel Deaconess Medical Center, Inc., Aalborg University, Resalis Therapeutics srl
InventorsPier Paolo Pandolfi, Riccardo Panella, Sakari Kauppinen, Andreas Petri
Life of this patent
Estimating the term…
Abstract
The present disclosure provides compositions and methods that inhibit the activity of microRNAs, for example miR-22.
Claims6
A miR-22 inhibitory composition comprising a nucleic acid having a sequence selected from the group consisting of:
- G*T*t*c*T*TC*a*A*c*T*G*g*C*a*g*C*T (SEQ ID NO:
- 17), G*T*t*C*t*T*c*A*a*CT*g*g*c*A*g*C*T (SEQ ID NO:
- 19), and G*T*t*c*T*T*c*A*a*C*t*g*G*CA*g*C*T (SEQ ID NO:
- 20), wherein the capital letters are LNA modifications, the lower case are unmodified, the symbol * denotes PS linkages, and the absence of the * symbol denotes PO linkages.
1 more element
Dependencies are inferred from the claim text.