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US 12,691,131 B2Granted
Liposomal formulations, and methods of using and preparing thereof
AssigneeGlycomine, Inc.
InventorsAgnes Rafalko, Teppei Shirakura, Samuel Eric Greenberg
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Abstract
The disclosure provides phosphorylated carbohydrate replacement therapies (CRT) that include compositions of phosphorylated carbohydrates and phospholipids, as well as methods for preparing such compositions. Such compositions are suitable for pharmaceutical delivery of phosphorylated carbohydrates to cell interior, endoplasmic reticulum, and Golgi, and can be used for treating CDG type I and CDG type II diseases as well as other metabolic disorders.
Claims16
A pharmaceutical composition comprising:
- a liposome comprising:
- i) 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE), or a salt thereof, present in an amount between about 30 mol % and about 50 mol %;
- ii) 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC), or a salt thereof, present in an amount between about 45 mol % and about 75 mol %;
- and
- iii) 1,2-distearoyl-sn-glycero-3-phosphoethanolamine (DSPE), or a salt thereof, conjugated to polyethylene glycol (PEG), present in an amount between about 0.1 mol % and about 10 mol %;
- and
- mannose-1-phosphate or a salt thereof encapsulated in the liposome.
4 more elements
Dependencies are inferred from the claim text.