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US 12,691,082 B2Granted
Oral administration of ketamine
AssigneeVitalis Analgesics LLC
InventorJoseph Habboushe
Life of this patent
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Abstract
Disclosed are pharmaceutical compositions having a portion of ketamine for intraoral release and another ketamine for gastrointestinal release. The compositions can further include aspirin. The disclosed formulations and related administration approaches improve the bioavailability and efficacy of oral ketamine.
Claims7
A compressed bilayer tablet comprising (a) a first composition comprising a first amount of ketamine and (b) a second composition comprising a second amount of ketamine,
- wherein the first composition is chewable and formulated to disintegrate or dissolve intraorally in a subject providing rapid release of the ketamine of the first composition in the subject, and the second composition comprises enteric coating and is formulated to be ingested and released in the gastrointestinal tract of the subject, and wherein the second composition is enclosed within the first composition.
Dependencies are inferred from the claim text.