Cationic lipids and preparation method thereof
AssigneeRiboX Therapeutics HK Limited
InventorRoi Mashiach
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Abstract
The present invention provides cationic lipids and lipid nanoparticle formulations comprising these lipids, alone or in combination with other lipids. These lipid nanoparticles may be formulated with nucleic acids to facilitate their intracellular delivery both in vitro and for therapeutic applications. The present invention also provides methods of chemical synthesis of these lipids.
Claims12
A cationic lipid, or a salt, hydrate, solvate, polymorph, optical isomer, geometrical isomer, enantiomer, diastereomer, tautomer, isotope labeled compound or mixtures thereof, wherein the cationic lipid is represented by the structure of formula (IV):
- wherein
- R1-L- is
- R2 and R3 are each independently Cp alkylene-Z—Cq alkyl;
- Z, at each occurrence, is independently —O—C(═O)— or —C(═O)—O—;
- p, at each occurrence, is independently an integer selected from 4, 5, 6, 7, 8, 9, or 10;
- and
- q, at each occurrence, is independently an integer selected from 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21 or 22.
Dependencies are inferred from the claim text.