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US 12,691,065 B2Granted
Liposome formulations for treatment of cancers and drug resistance of cancers
AssigneeNanoTech Pharma Inc.
InventorsFang Liu, Xian Xu
Life of this patent
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Abstract
Disclosed herein are liposomal pharmaceutical compositions encapsulating one or more anticancer agents and methods of using the liposomal pharmaceutical compositions for treating cancers, in which multiple anticancer agents can be administered to a cancer patient in a synergistic molar ratio through liposome delivery particles. Methods of preparing the liposomes encapsulating multiple anticancer agents and the pharmaceutical compositions thereof are also disclosed.
Claims22
A pharmaceutical composition comprising liposomes suspended in a liquid medium, wherein the liquid medium comprises water and a pH buffer agent;
- wherein the liposome comprises an interior compartment surrounded by an outer lipid bilayer membrane, wherein the interior compartment comprises a hydrophilic chemotherapeutic agent, a protein kinase inhibitor, and a trapping agent selected from ammonium or substituted ammonium salts of polyanionized sulfobutyl ether cyclodextrin, ammonium or substituted ammonium salts of polyanionized sulfated carbohydrates, ammonium or substituted ammonium salt of polyphosphate, transition metal salts, quaternary ammonium compounds, polyoxyethylene, and coconut amine, in an aqueous medium;
- wherein the lipid bilayer membrane comprises a hydrophilic inner surface forming the interior compartment, a lipophilic bilayer, and a hydrophilic outer surface in contact with the liquid medium of the composition;
- and wherein the hydrophilic chemotherapeutic agent and protein kinase inhibitor can be released from the liposomes in a synergistic mode.
Dependencies are inferred from the claim text.