Automated drug filling process
AssigneeAmgen Inc.
InventorsBenjamin J. Adams, Mingfen Tsai
Life of this patent
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Abstract
An automatic drug substance (DS) fill system is provided, comprising: a plurality of pumps, each configured to fill a respective DS container; a plurality of weighing scales, each configured to measure weights associated with each respective DS container; and a controller configured to: cause each of the plurality of pumps to fill each respective DS container; monitor the weights associated with each respective DS container measured by the weighing scales; compare the weights associated with each respective DS container, measured by the weighing scales, to a threshold weight; and cause each of the plurality of pumps to cease filling each respective DS container based on the weight associated with their respective DS container reaching the threshold weight.
Claims12
An automatic drug substance (DS) fill system, comprising:
- a plurality of pumps, each pump configured to fill a respective DS container of a plurality of DS containers;
- a plurality of weighing scales, each weighing scale configured to measure weights associated with each respective DS container of the plurality of DS containers;
- and
- a controller configured to:
- cause each of the plurality of pumps to simultaneously fill each respective DS container, of the plurality of DS containers;
- monitor the weights associated with each respective DS container of the plurality of DS containers measured by each of the plurality of weighing scales;
- compare the weights associated with each respective DS container, of the plurality of DS containers measured by each of the plurality of weighing scales, to a threshold weight;
- and
- independently control each pump of the plurality of pumps to cease filling each respective DS container based on the weight measured by the weighing scale associated with a respective pump's respective DS container reaching the threshold weight.
An automatic drug substance (DS) fill system, comprising:
- a plurality of pumps, each pump configured to fill a respective DS container of a plurality of DS containers;
- a tubing manifold configured to connect a fill line from a DS source to each of the plurality of pumps via a sealed, sterile connection;
- a plurality of sensors, each sensor configured to measure a volume of a DS flowing from each of the plurality of pumps into each respective DS container of the plurality of DS containers;
- and
- a controller configured to:
- cause each of the plurality of pumps to simultaneously fill each respective DS container, of the plurality of DS containers;
- monitor the fill volume from each of the plurality of pumps into each respective DS container into the plurality of DS containers;
- compare the fill volume associated with each respective DS container, of the plurality of DS containers, measured by each of the sensors, to a threshold volume;
- and
- independently control each pump of the plurality of pumps to cease filling based on the fill volume measured by the sensor associated with a respective pump's respective DS container reaching the threshold volume.
An automatic drug substance (DS) fill method, comprising:
- causing, by a controller, each of a plurality of pumps to simultaneously fill each a respective DS container, of a plurality of DS containers;
- monitoring, by a plurality of sensors, each sensor associated with a respective DS container of the plurality of DS containers, fill volumes associated with each respective DS container;
- comparing, by the controller, the fill volumes associated with each respective DS container, of the plurality of DS containers measured by each of the plurality of sensors to a threshold volume;
- and
- independently controlling, by the controller, each pump of the plurality of pumps to cease filling each respective DS container based on the fill volume measured for a respective pump's respective DS container reaching the threshold volume.
Dependencies are inferred from the claim text.