Pulsed field electroporation systems and methods

A method comprising:

• inserting an elongated shaft of a Pulsed Field Electroporation (PFE) delivery instrument into a nose site having targeted nasal tissue such that an adjustable PFE electrode of a treatment tip at a distal end of the PFE delivery instrument is adjacent to the targeted nasal tissue, wherein the elongated shaft defines an inflation lumen that extends through the elongated shaft across an entire axial length of the PFE electrode such that one or more distal sidewall fluid ports of the inflation lumen are located distally of a distal-most end of the PFE electrode;
• adjusting the PFE electrode relative to the elongated shaft by delivering an inflation fluid through the inflation lumen that extends across the entire axial length of the PFE electrode so as to compress the PFE electrode against the targeted nasal tissue, the inflation fluid being delivered through said one or more distal sidewall fluid ports of the inflation lumen located distally of the distal-most end of the PFE electrode, through one or more proximal sidewall fluid ports of the inflation lumen located proximally of a proximal-most end of the PFE electrode, and through one or more intermediate sidewall fluid ports of the inflation lumen located between of the distal-most end of the PFE electrode and the proximal-most end of the PFE electrode, wherein the inflation lumen extends distally beyond said one or more distal sidewall fluid ports;
• activating a PFE generator of a control console connected to the PFE delivery instrument to output, via a conductor connected to the PFE electrode, an electric field in a predefined pattern from the PFE electrode to induce at least one of irreversible electroporation (IRE) at the targeted nasal tissue and reversible electroporation (RE) at the targeted nasal tissue, wherein the conductor is located within a conductor lumen that extends through the elongated shaft to a conductor sidewall opening that is proximal to the PFE electrode, and wherein the conductor passes through the conductor sidewall opening and extends distally from the conductor sidewall opening and along a surface of the treatment tip to connect to the PFE electrode at a connection point, the conductor extending distally along the surface of the treatment tip between the conductor sidewall opening and the connection point, an entire length of the conductor between the sidewall opening and the connection point located radially outward of the surface of the treatment tip.