Catalytic reactive oxygen species scavenger hydrogel
AssigneeSenseonics, Incorporated
InventorsLeopoldo Torres, Jr., Venkata Velvadapu, Lily Granzow
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Abstract
A medical device (e.g., an analyte sensor) that may be implanted within a living animal (e.g., a human) and may be used to measure an analyte (e.g., glucose or oxygen) in a medium (e.g., interstitial fluid, blood, or intraperitoneal fluid) within the animal. The medical device may include a polymer covering at least a portion of a surface of the medical device and a plurality of reactive oxygen species (ROS) scavenger molecules covalently linked to the polymer (e.g., to reduce degradation of an analyte indicator including the polymer).
Claims63
A sensor for measurement of an analyte in a medium within a living animal comprising:
- a sensor housing;
- an analyte indicator covering at least a portion of the sensor housing, and the analyte indicator comprises a polymer;
- and
- a plurality of reactive oxygen species (ROS) scavenger molecules covalently linked to the polymer, wherein the ROS scavenger molecules comprise
- or a combination thereof.
A method of fabricating a sensor for measurement of an analyte in a medium within a living animal, the method comprising:
- applying an analyte indicator to a sensor housing of the sensor such that the applied analyte indicator covers at least a portion of the sensor housing, wherein the analyte indicator comprises a polymer;
- and
- coupling a plurality of reactive oxygen species (ROS) scavenger molecules covalently to the polymer, wherein the ROS scavenger molecules comprise
- or a combination thereof.
A sensor for measurement of an analyte in a medium within a living animal comprising:
- a sensor housing;
- an analyte indicator covering at least a portion of the sensor housing, wherein the analyte indicator comprises a polymer;
- and
- a plurality of reactive oxygen species (ROS) scavenger molecules covalently linked to the polymer via a monomer spacer molecule attached to the polymer, wherein the plurality of ROS scavenger molecules are covalently linked to the monomer spacer molecule via a coupling bond, wherein the coupling bond is an amide bond, a carbon-thiol bond, a malamide-thiol bond, or a triazole bond.
Dependencies are inferred from the claim text.