Methods for magnetic resonance imaging of nanoconstructs and uses thereof

A method of imaging a magnetic resonance imaging (MRI) agent, the method comprising:

• (a) administering the MRI agent to a subject, wherein the MRI agent comprises nanoconstructs each having a plurality of equivalent protons and an average molecular weight in a range of about 300 Da to about 300 kDa, and the nanoconstructs each have a T2 relaxation time greater than at least about 250 ms;
• (b) using an MRI device to obtain a nuclear magnetic resonance scan of the that selectively images the nanoconstructs, wherein (b) comprises:
• (i) scanning the subject with the MRI device, using
• a signal acquisition bandwidth ranging from at least about 2 kHz to about 200 KHz and
• greater than 8 spin echoes, so that signals from both (A) the plurality of equivalent nanoconstruct protons and (B) water protons are obtained;
• and
• (ii) applying diffusion filtering to suppress the water proton signals from the scan,
• so that the nuclear magnetic resonance scan that selectively images the nanoconstructs is obtained.