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US 12,687,554 B2Granted
Molecular profiling of tumors
AssigneeCaris MPI, Inc.
InventorsDaniel D. Von Hoff, David M. Loesch, Arlet Alarcon, Robert J. Penny, Alan Wright, Matthew J. McGinniss, Ryan P. Bender, Traci Pawlowski
Life of this patent
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Abstract
Provided herein are methods and systems of molecular profiling of diseases, such as cancer. In some embodiments, the molecular profiling can be used to identify treatments for a disease, such as treatments that were not initially identified as a treatment for the disease or not expected to be a treatment for a particular disease.
Claims33
A computer system comprising:
- one or more processors;
- and
- computer memory that is in communication with the one or more processors and stores instructions that, when executed by the one or more processors, perform operations comprising:
- obtaining data that is indicative of results of a performance of one or more molecular tests for a plurality of molecular profiling targets of a biological sample obtained from a patient that has a particular cancer type, wherein the one or more molecular tests comprise at least one selected from a group consisting of gene expression analysis and nucleic acid sequence analysis;
- accessing, without using the particular cancer type, a first database of the computer system to obtain corresponding reference values;
- comparing the obtained data to the corresponding reference values obtained from the first database of the computer system, wherein the corresponding reference values are not associated with the particular cancer type in the first database as part of the comparing;
- accessing the first database or another database to identify, from the comparing, at least one therapeutic agent based on an indication that the comparison indicates a likely benefit to the patient of the at least one therapeutic agent;
- and
- generating a patient profile report that presents the at least one therapeutic agent as a suitable agent for the patient.
6 more elements
A method comprising:
- obtaining, by a computer system, data that is indicative of results of a performance of one or more molecular tests for a plurality of molecular profiling targets of a biological sample obtained from a patient that has a particular cancer type, wherein the one or more molecular tests comprise at least one selected from a group consisting of gene expression analysis and nucleic acid sequence analysis;
- accessing, by the computer system without using the particular cancer type, a first database of the computer system to obtain corresponding reference values;
- comparing, by the computer system, the obtained data to the corresponding reference values obtained from the first database of the computer system, wherein the corresponding reference values are not associated with the particular cancer type in the first database as part of the comparing;
- accessing, by the computer system, the first database or another database to identify, from the comparing, at least one therapeutic agent based on an indication that the comparison indicates a likely benefit to the patient of the at least one therapeutic agent;
- and
- generating, by the computer system, a patient profile report that presents the at least one therapeutic agent as a suitable agent for the patient.
3 more elements
One or more non-transitory computer-readable storage medium storing instructions that, when executed by one or more computers, cause the one or more computers to perform operations, the operations comprising:
- obtaining data that is indicative of results of a performance of one or more molecular tests for a plurality of molecular profiling targets of a biological sample obtained from a patient that has a particular cancer type, wherein the one or more molecular tests comprise at least one selected from a group consisting of gene expression analysis and nucleic acid sequence analysis;
- accessing, without using the particular cancer type, a first database of the one or more computers to obtain corresponding reference values;
- comparing the obtained data to the corresponding reference values obtained from the first database of the one or more computers, wherein the corresponding reference values are not associated with the particular cancer type in the first database as part of the comparing;
- accessing the first database or another database to identify, from the comparing, at least one therapeutic agent based on an indication that the comparison indicates a likely benefit to the patient of the at least one therapeutic agent;
- and
- generating a patient profile report that presents the at least one therapeutic agent as a suitable agent for the patient.
3 more elements
Dependencies are inferred from the claim text.