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US 12,687,483 B2Granted
Optical particle analyser with illumination at an oblique angle onto a non-transparent microfluidic chip
AssigneeCellular Highways Ltd.
InventorAlex Zhukov
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Abstract
An optical particle analyser is provided; the analyser comprising: a microfluidic chip comprising: a flow channel for carrying particles; the flow channel arranged between a transparent window and a non-transparent substrate; a light source configured to emit an illumination beam towards the flow channel; wherein the microfluidic chip and the light source are arranged such that, in use, the illumination beam impinges the window at an oblique angle of incidence. By providing the optical particle analyser in this manner, high performance particle analysis may be accurately carried out.
Claims13
An optical particle analyser, comprising:
- a microfluidic chip having a flow channel for carrying particles arranged between a transparent window and a non-transparent substrate, at least a portion of the flow channel having a rectangular cross section;
- and
- a light source configured to emit an illumination beam towards the flow channel,
- wherein the microfluidic chip and the light source are arranged such that, in use, an angle of incidence of the illumination beam impinges the transparent window at an oblique angle;
- a particle focusing mechanism configured to concentrate the particles within the flow channel;
- wherein the particle focusing mechanism is configured to produce two particle foci;
- wherein each particle foci are aligned with respect to a plane of the microfluidic chip;
- and
- wherein the light source is further configured such that the illumination beam uniformly illuminates the particles in the flow channel.
6 more elements
Dependencies are inferred from the claim text.