Methods of treating cancer by suppression of FAMIN expression
AssigneeCambridge Enterprise Limited
InventorsArthur Kaser, Mohammed Zaeem Cader
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Abstract
This invention relates to the finding that inhibition or inactivation of FAMIN (‘fatty acid metabolism—immunity nexus’; C13orf31: LACC1 (laccase domain containing 1)) reduces tumourigenesis and stimulates cell-mediated immune responses. Method of treating cancer orstimulating cell-mediated immune responsesin an individual by reducing FAMIN activity in the individual are provided. Also provided are methodsofactivating T cells in vitro using FAMIN deficient immune cells and stimulating cell-mediated immune responses comprising administering(a) a population of FAMIN deficient immune cells; or(b) a population of T cells activated in vitro by a population of FAMIN deficient immune cells.
Claims8
A method of decreasing the proliferation of tumour cells comprising;
- contacting the cells with a suppressor nucleic acid or targeted nuclease that reduces expression of active FAMIN polypeptide, wherein the active FAMIN polypeptide comprises an amino acid sequence at least 95% identical to SEQ ID NO:
- 1 over the whole length of SEQ ID NO:
- 1,
- wherein the suppressor nucleic acid comprises a contiguous sequence of 15 to 40 nucleotides of a nucleotide sequence at least 95% identical to SEQ ID NO:
- 2 or its complement.
Dependencies are inferred from the claim text.