Recombinant human sialidases, sialidase fusion proteins, and methods of using the same
AssigneePalleon Pharmaceuticals Inc.
InventorsLi Peng, Lizhi Cao, Lihui Xu
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Abstract
The invention relates generally to recombinant human sialidases and recombinant sialidase fusion proteins, wherein the sialidase optionally contains one or more mutations compared to wild-type human sialidase, e.g., a substitution, deletion, or addition of at least one amino acid. The invention also provides antibody conjugates including a sialidase and an antibody or a portion thereof. The invention further relates to methods of using the sialidase fusion proteins or antibody conjugates for treating cancer.
Claims20
A recombinant mutant human sialidase enzyme comprising an amino acid sequence having at least 90% sequence identity to SEQ ID NO:
- 1;
- a substitution of the methionine residue at position 1 of SEQ ID NO:
- 1;
- and sialidase enzymatic activity.
Dependencies are inferred from the claim text.